When F.B.I. Special Agent Joe Merriwether (Jeffrey Dean Morgan) is unable to solve a series of homicides, he decides to enlist the help of his former colleague Dr. John Clancy (Sir Anthony Hopkins), a retired physician with psychic powers. The reclusive Clancy, who shuttered his practice and retreated from the world following the death of his daughter and subsequent break-up of his marriage, wants nothing to do with the case. He soon changes his mind after seeing disturbingly violent visions of Joe's partner, F.B.I. Special Agent Katherine Cowles' (Abbie Cornish's) ultimate demise. When Clancy's exceptional intuitive powers put him on the trail of a suspect, Charles Ambrose (Colin Farrell), the doctor soon realizes his abilities are no match against the extraordinary powers of this vicious murderer on a mission.