It is with mixed emotions that Eloise McGarry accepts the invitation to attend the wedding of Francie Millner and Douglas Grotsky, the festivities to take place at an upscale resort on an island on a lake, the island accessible only by ferry. The issue is that Francie is her oldest friend and she was to be Francie's maid of honor up until two months ago when Francie's brother, Teddy Millner, her boyfriend at the time and Doug's best man, unceremoniously dumped her via text message after dating for two years. Teddy's current girlfriend, Nikki, who he dated before Eloise, also replaced Eloise as maid of honor after Eloise already organized most of the wedding. Eloise doesn't want her and Teddy's issues to overshadow Francie and Doug's big day, they, who indirectly through Nikki, don't want her to either in moving her to Table 19 of nineteen at the reception, which Eloise knows is the table not only of the misfits, but those who were not smart enough to realize they really weren't wanted to attend the wedding. The others at Table 19 are: Jo Flanagan, Francie and Teddy's first nanny when they were kids; always bickering married couple Bina and Jerry Kepp, diner owners, acquaintances of Doug's father who owns a chain of diners, the Kepps who weren't even seated with other such acquaintances; high schooler Renzo Eckberg, whose mother encouraged him to attend instead of going to his high school prom as a better prospect to lose his virginity as no one at the reception knows him; and Mr. Millner's socially awkward nephew Walter Thimble, his uncle who never expected him to show up "under the circumstances". Once Eloise is able to convince those that were incredulous as to their status at the reception of being at Table 19, they all slowly begin to open up about their misfit status, which leads to some issues which none of those seated at that table thought they would be discussing with anyone at the wedding let alone total strangers they just met. Foremost, they want to help Eloise find true happiness especially in light of her situation, that happiness which may include finding a mysterious white knight in shining armor at the reception that Eloise only knows as Huck, possibly to replace Teddy in her heart and life.