In New York, the arrogant Dr. Stephen Strange is a talented neurosurgeon with a huge ego. After a car accident, Dr. Strange damages his fingers and loses control of his hands. The surgeon, Christine Palmer, who was his lover, tries to help him. But Dr. Strange unsuccessfully spends his savings searching for an experimental treatment for his fingers. When Dr. Strange learns that the paraplegic Jonathan Pangborn walked again, he seeks him out and is told he was healed in Kamar-Taj. Dr. Strange travels to Katmandu where he meets the sorcerer Mordo and is introduced to The Ancient One. She discloses the astral plan and other dimensions to him and explains that Earth is protected in the mystical plan by three Sanctums (in New York, London, and Hong Kong). However, her former protégé, Kaecilius, has contacted the powerful demon Dormammu in the Dark Dimension and wants to destroy the three Sanctums with his minions to let the Dark Dimension, where time does not exist and anyone can live forever, to rule the world. Will The Ancient One, Dr. Strange and Mordo save the world?